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MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
1. A 28-year-old woman was referred with an 8-year history of progressive weight gain, hypertension and abdominal striae. She had no family history of note and was not taking any medication.
On examination, her blood pressure was 158/86 mmHg. There was central obesity with abdominal striae. There was mild proximal myopathy of the lower limbs.
Investigations:
serum sodium143 mmol/L (137-144)
serum potassium3.4 mmol/L (3.5-4.9)
low-dose dexamethasone suppression test (2 mg/day for 48 h):
serum cortisol180 nmol/L (<50)
An MR scan of pituitary showed an invasive adenoma extending laterally into the cavernous sinuses bilaterally. Superiorly, the adenoma was in contact with, but not distorting, the optic chiasm. Formal visual field examination was normal.
What is the most appropriate next step in management?
A) somatostatin agonist therapy
B) pituitary radiotherapy
C) bilateral adrenalectomy
D) trans-sphenoidal hypophysectomy
E) adrenolytic therapy
2. A 33-year-old woman was seen for diabetes review 2 months after her first pregnancy. Diabetes mellitus had been diagnosed at 18 weeks' gestation. She had experienced no symptoms; routine urinalysis had shown glucose 4+, with no ketones, and her fasting blood glucose concentration was 6.2 mmol/L (3.0-6.0), rising to 13.5 mmol/L (<7.8) in a 75-g oral glucose tolerance test. She had been treated with insulin during the pregnancy, and stopped after delivery. Her mother and maternal aunt had been treated for type 2 diabetes mellitus, and a maternal uncle for type 1 diabetes. Her body mass index was 23.7 kg/m2 (18-25).
Without insulin she remained well, with no osmotic symptoms, no weight loss and no ketosis.
Investigations:
fasting plasma glucose8.4 mmol/L (3.0-6.0)
haemoglobin A1c68 mmol/mol (20-42)
oral glucose tolerance test (75 g):
fasting plasma glucose7.9 mmol/L (3.0-6.0)
2-h plasma glucose13.8 mmol/L (<7.8)
serum insulin72 pmol/L (<186)
serum C-peptide945 pmol/L (180-360)
A trial of therapy with gliclazide 40 mg once daily led to a significant improvement in her blood glucose.
What is the most likely cause of her diabetes?
A) type 1 diabetes mellitus
B) type 2 diabetes mellitus
C) latent autoimmune diabetes in adulthood
D) maturity-onset diabetes of the young caused by glucokinase mutation
E) maturity-onset diabetes of the young caused by HNF-1? mutation
3. A 64-year-old man presented with palpitations, fatigue and malaise. Two months previously, he had sustained an acute myocardial infarction complicated by ventricular tachycardia and cardiac arrest, and had been discharged taking amiodarone 200 mg daily.
On examination, he appeared well, his pulse was 90 beats per minute and regular, and he
had mild tremor of his hands but no other abnormal signs.
Investigations:
serum thyroid-stimulating hormone6.2 mU/L (0.4-5.0)
serum free T418.2 pmol/L (10.0-22.0)
serum free T34.8 pmol/L (3.0-7.0)
What is the most appropriate next step in management?
A) discontinue amiodarone
B) repeat thyroid function tests in 2 months
C) repeat thyroid function tests in 12 months
D) start levothyroxine
E) isotope scan of thyroid
4. A 69-year-old man with type 2 diabetes mellitus presented with a 3-day history of an ulcer on his right second toe.
On examination, the toe was red, swollen and enlarged, and looked like a 'sausage digit'. The ulcer appeared superficial.
Investigations:
X-ray of right second toeno sign of osteomyelitis
Cultures from the debrided wound bed were taken and the results were awaited.
What is the most appropriate type of antibiotic regimen to start empirically before the culture results are available?
A) broad spectrum for 10 days
B) broad spectrum for 6 weeks
C) narrow spectrum for 6 weeks
D) no antibiotic
E) narrow spectrum for 10 days
5. A 54-year-old woman attended clinic for routine follow-up. She had Cushing's syndrome secondary to ectopic adrenocorticotropic hormone syndrome with no primary source identified.
She had declined bilateral adrenalectomy. Routine medication included metyrapone 500 mg three times daily, ketoconazole 200 mg once daily and hydrocortisone 10 mg in the morning and 5 mg in the evening.
Metyrapone inhibits the action of which enzyme in steroidogenesis?
A) 17?-hydroxylase
B) 21-hydroxylase
C) 3?-hydroxysteroid dehydrogenase
D) 11?-hydroxylase
E) 5?-reductase
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: E | Question # 3 Answer: B | Question # 4 Answer: C | Question # 5 Answer: D |






